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E.A.von Willebrand,
finnish physician who first described vascular hemophilia.
Е.А. фон Виллебранд (1870-1949), финский врач.
In 1924, Georg Haas (1886-1971)
from the small German town of Giessen was the first to perform an
extracorporal hemodialysis on a uremic patient. Purified hirudin was
used as anticoagulant for this experiment that lasted only 15
minutes and came off without complications. Haas calculated from
measurements of indican concentration in blood and dialysate that
150 ml of blood had been cleansed. In 1925-26, Haas dialyzed five
additional patients. In 1927, at his seventh experiment, Haas
conducted hemodialysis using for the first time as anticoagulant
heparin, discovered by Erik Jorpes. The necessarily short dialysis
time presumably coupled with low blood flows and small dialysate
volumes prevented the dialyses from having any significant
therapeutic effect. In a lecture to the Giessen Medical Society in
January 1928, Haas detailed the results of three blood cleansings,
as he termed them, in two patients with chronic uremia. He concluded
his lecture with the comment "Despite the limited number of
observations, I have already gotten the distinct impression that it
is worth the effort to continue along the path taken." But Haas did
not continue along that path, apparently because of lack of support
from his medical community.
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